Fibrodysplasia Ossificans Progressiva

Fibrodysplasia Ossificans Progressiva is a rare genetic disorder in which connective tissue and muscle tissue are gradually ossified. Extra-skeletal bone formation causes progressive loss of mobility. The process starts in early childhood and often forms a pattern starting with the neck and shoulders and proceeding down the body into the limbs. Ossification happens spontaneously or after trauma. The prevalence is approximately 1:2.000.000 and no ethnic, racial or geographic predisposition has been described.

Trauma is an important factor in heterotopic ossification in FOP, therefore (intramuscular) injections, biopsies, and other invasive procedure are strongly advised against.

A mutation in activin receptor IA/ activin-like kinase 2 (ACVR1/ALK2), a bone morphogenetic protein (BMP) type I receptor, is the cause of all sporadic and familial cases of classic FOP.

17 June 2021

• Congenital hallux valgus
• Heterotopic ossification

• d 410 Changing basic body position
• d 420 Transferring oneself
• d 430 Lifting and carrying objects
• d 445 Hand and arme use
• d 450 Walking
• d 460 Moving around in different locations
• d 465 Moving around using equipment
• d 470 Using transportation
• d 475 Driving
• d 530 Toileting
• d 510 Washing oneself
• d 520 Caring for body parts
• d 540 Dressing
• d 550 Eating
• d 560 Drinking
• d 630 Preparing meals
• d 640 Doing housework
• d 650 Caring for household objects
• d 830 Higher education
• d 835 Education life
• d 845 Acquiring, keeping and terminating a job
• d 930 Religion and spirituality
• d 920 Recreation and leisure
• d 4750 Driving human-powered transportation