Splenomegaly in thalassemia

Splenomegaly (enlarged spleen) is common in thalassemia major and intermedia due to the high rate of hemolysis (red blood cell destruction). The spleen detects the defective red cells of the thalassemic as deficient and removes these from the circulation. The hyperactivity of the spleen results in splenomegaly. The enlarged spleen may be accompanied by an enlarged liver.

Last modified
19 August 2018
B87 Splenomegaly

Large spleen or splenomegaly is usually detected at regular physical examinations. TheĀ enlarged spleen is usually felt about 1-2 cm below the left costal margin. A...

Rare Condition

Thalassemia major or Beta Thalassemia

The thalassemias are a group of genetically (inherited) blood disorders that share in common one feature; the defective production of hemoglobin which is the protein...