Large spleen

Large spleen or splenomegaly is usually detected at regular physical examinations. The enlarged spleen is usually felt about 1-2 cm below the left costal margin. A large spleen is a feature of for example

  • Thalassemia
  • Infections
  • Nieman Pick disease
  • Gaucher disease
Last modified
30 May 2019
Splenomegaly (enlarged spleen) is common in thalassemia major and intermedia due to the high rate of hemolysis (red blood cell destruction). The spleen detects the...
Rare Condition

Thalassemia major or Beta Thalassemia

The thalassemias are a group of genetically (inherited) blood disorders that share in common one feature; the defective production of hemoglobin which is the protein...