X linked family history

Some diseases only, or mainly, effect males. This occurs when the abnormal gene is on the X chromosome. Because men have one X chromosome and woman two, in recessive X linked diseases the normal X chromosome in the female will compensate to some extent the effect of the abnormal gene. Carrier mothers have a 50% chance of passing the X chromosome to their sons, who will have the disease. A boy will not get an X-linked disease from his father since boys get their fathers Y chromosome. Unlike X-linked recessive diseases, dominant X-linked diseases do effect females. Examples of X linked disorders:

Last modified
25 August 2019
Symptom

X linked dominant hypophosphathemia

XLH is inherited in an X-linked dominant manner. This is because the gene responsible for the condition is located on the X chromosome, and having...

X Linked semi dominant inheritance

The Coffin-Lowry gene (RPS6KA3) is located on the X chromosome (Xp22.2). Girls may express symptoms of CLS. Most of the persons with CLS are the...
Rare Condition

Coffin Lowry Syndrome

Coffin Lowry syndrome is a rare genetic disorder characterized by

  • mental retardation;
  • abnormalities of the head and facial (craniofacial) area;
  • large, soft hands with short...

X Linked Hypophosphatemia

X-linked hypophosphatemia (XLH) is known as the most common hereditary metabolic rickets with a prevalence of 1:20,000- 60,000. Manifestations are bone deformities (particularly bowing of...

Duchenne Muscular Dystrophy

Duchenne muscular dystrophy is an inherited, X-linked disease that affects about 1 in 3500 - 6000 males. DMD occurs as a result of a change...