Vaso-occlusive crisis

Acute pain in extremities, the back, or the belly is caused by vascular occlusion in the blood vessels of the bone or gut.

Children with unexplained (bone) pain should be screened for sickle cell disease.

Sickle cell disease manifests at about the age of 6 months, when the fetal hemoglobin is almost completely replaced by hemoglobin S, commonly in the In the first 4 years of life.

Still in a smallĀ group of individuals sickle cell disease will manifest in their teens.

Heijboer et al. Ned Tijdschr Geneeskd. 2007;151:2498-501

Last modified
21 November 2018

Recurrent bone pain in a child may indicate for example:

Rare Condition

Sickle Cell Disease

Sickle cell disease (SCD) is a red blood cellĀ disease, a complex inherited disorder with multisystem manifestations that requires specialized comprehensive care to achieve an optimal...


Vaso-occlusive crisis- Pain

The most common complication in SCD is...